Igangværende forskning

• Hepatitis C virus Genotype 2 – Et fylogenetisk studie.
• Leverfibrose – Et translationelt studie i mekanismerne ved hepatisk fibrogenese.
• Karakterisering af HNPCC patienter med manglende ekspression af MLH1 og PMS2 ved analyse af promoter regionerne og screening for mutationer i regulatoriske enzymer (p53).
• Studie af mutationsprofiler og sammenhængen med infektionsforløb hos danske patienter inficeret med Hepatitis B Virus genotype D.
• Diagnostisk potentiale af metyleret DNA i ovariecancer.
• Præanalytiske forholds betydning for genekspressionsprofiler.
• Forekomst af fænotypiske varianter i xenobiotika metaboliserende enzymer og haptoglobin hos patienter med gastroenterologiske sygdomme
• Genetiske varianter som predictor for respons på azathioprin behandling hos patienter med IBD.
• Prospektiv undersøgelse af venøs trombose. Betydning af genetiske og livsstilsrelaterede risikofaktorer.
• Characterisation of functional antithrombin variants causing thrombosis.
• Backscatterinterferometri
• Atrieflimren – er det en hyperkoagulabel tilstand
• The association between cardiac diseases, non-alcoholic fatty liver disease and circulating microparticles in obesitas and type 2 diabetes.
• Platelet response to aspirin and clinical outcome in patients with peripheral atherosclerosis – 5 years follow-up.
• The procoagulant state of patients with multiple myeloma and monoclonal gammopathia of unknown significans (MGUS). The role of the M-component.
• Optimization of the analysis thrombin generation
• Optimization and evaluation of various techniques for determination of number, size and thrombogenicity of microvesicles.
• The procoagulant state of patients with small cell lung carcinoma.
• sCD36 as a marker of weight loss induced improvements in body fat distribution, insulin sensitivity and fatty liver.
• Development of algoritm for degree of fatty liver in obese children.
• Method development for the quantification of disease associated membrane proteins on circulating microparticles.
• Circulating CD36 as a risk marker of CVD – follow up study

Deltagelse i andre forskningsprojekter:

• Mutationer i MSH6 blandt danske HNPCC familier
• Karakterisering af mutationer i PMS1 og PMS2 ved insilico og exon trapping analyser i samarbejde med Klinisk Biokemisk Afdeling, Rigshospitalet.
• MOMA Study – Modifier of MMR
• Hypodonti og ovariecancer
• HDV genotypning – Grønlandsprojekt
• Biofysiske og kinetiske undersøgelser af Antitrombin, vildtype og varianter
• Classification of BRCA1 and BRCA2 variants of unknown significance
• Investigation of BRCA1 and BRCA2 risk – modifiers
• Characterisation of BRCA2 variants causing Exon3-skipping
• Comparison of MRNA splicing assay protocols and reporting practices across multiple international laboratories identifies a need for standardized assay design and detection for clinical assays.
• Hyper- og hypomethylering ved kolorektalcancer
• Hyper- og hypomethylering ved pancreascancer
• Exosome Array: Microarray capturing and detection of exosomes for multiplexed phenotyping.
• Venous thromboembolism and hypercoagulability in upper gastrointestinal cancer
• Gene Variants and Risk of Venous Thromboembolism (GIANT) - A multicenter validation study
• Cancer and the risk of venous thrombosis – a Scandinavian multicenter study
• Metabonomics in patients with acute lung injury
• Bone resorption in diabetes – new markers and interference studies I samarbejde med Endokrinologisk afd. Aalborg Universitetshospital