Stroke

Forskningsområder

Stroke forskning på Aalborg Universitetshospital bygger på et unikt enstrenget forløb med akut indlæggelse af alle stroke-patienter fra Region Nordjylland. Forskningen fokuserer på patientnær, primært klinisk forskning, med deltagelse i nationale og internationale multicenterstudier, som dækker det præhospitale forløb (visitation og behandling), den akutte behandling (cerebral iskæmi og hæmoragi) og sekundærprofylaksen. Forskergruppe er stødt voksende med et stigende antal forskningssemesterstuderende, flere Ph.D.-projekter og etablering af en post-docstilling.

Lokale studier

Ph.D-projekter

• Ph.D. Birgitte Hede Ebbesen: Development and preliminary testing of a patient-centered and evidence-based intervention for patients with Transient Ischemic Attack by exploring prognosis, impact on everyday life and return to work.

• Ph.D. Benjamin Svejgaard: A protocol of timed BCI-assisted physiotherapy (BCI training) can significantly improve rehabilitation in upper limb function in post-stroke patients.

• Ph.D. Jonas Hansen: Advancing Stroke Rehabilitation in North Denmark Region: Integrating Clinical Data, Artificial Intelligence, and Innovative Technologies.

Projekter

• Post-Doc Project: Risk of stroke and death in asymptomatic carotid artery stenosis: a Danish single-center retrospective cohort study.

• Review Birgitte Hede Ebbesen: Lasting impairments following Transient Ischemic Attack and minor stroke: A systematic review.

• Quality control Haider Faeq Hadhratee Al-Rubaiee:Acute brain cancer diagnostic in North Denmark Region.

• Registy research Søren Paaske:Validity of acute stroke diagnosis in the Danish Stroke Registry and the Danish National Registry of Patients.

• Research Paul von Weizel Mudersbach: Long-term patency and hemodynamic impact of extra-intracranial bypass surgery in atherosclerotic steno-occlusive disease.

• Ph.D. Milo Marsfeldt Skovfoged, Hendrik Knoche (AAU): Dansk virtuel assistent (VA) til patienter med stroke.

• Case report Haider Faeq Hadhratee Al-Rubaiee: Cerebral amyloid angiopathy-related inflammation (CAA-ri).

• Case report Haider Faeq Hadhratee Al-Rubaiee: Pregnancy as a pro-thrombotic state.

• Case series Christian Kirkedal: MRI-arterial spin labelling to uncover atypical migraine aura as stroke mimic: A case series.

• Experimental: Point of care diagnostic of stroke in a pig stroke model.

Multicenterstudier

Investigator driven research

• StrokeClose (RCT) Prevention of Stroke by Left Artrial Appendage Closure in atrial fibrillation patients after intracerebral hemorrhage: A multicenter Randomized Clinical Trial (recruiting)
  
• STATICH (RCT) Study of Antithrombotic Treatment after Intracerebral Haemorrhage (follow-up)
  
• OCCLUSION-AF (RCT) The OCCLUSION-AF Trial: Left Atrial Appendage Occlusion versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation. A Multicenter Randomized Clinical Trial (recruiting)
  
• TICH-III (RCT) Tranexamic acid for hyperacute spontaneous IntraCerebral Haemorrhage (pending)
  
• ASSET (RCT) Acute Subcutaneous Semaglutide in Acute Ischemic Stroke (pending)
  
• COMPEX (RCT) Computer-assisted self-training to improve executive function versus unspecific training in patients after Stroke, Cardiac arrest or in Parkinson’s Disease: A randomized controlled trial (pending)
  
• EXTEND (observational) Late window thrombolysis in patients with acute ischemic stroke – a prospective observational cohort study (pending)
  
• DANNOAC-AF (Cluster randomized study) Head-to-head compare of 4 different NOAK in patients with AF to assess efficacy in prevention and risk of bleeding (pending)
  
• ATLAAC Anticoagulant Therapy in patients with atrial fibrillation after surgical Left Atrial Appendage Closure: a randomized non-inferiority trial (pending)
  
• NORDIC-CBI A nordic pragmatic multicenter randomized trial on platelet inhibition and/or lipid lowering treatment in covert brain infarction (pending)

Medical industry driven 

• OCEANIC-STROKE (RCT) Phase 3 program of the Oral faCtor Eleven A iNhibitor asundexIan as novel anti-thrombotiC –STROKE study (recruiting)
  
• LIBREXIA-STROKE (RCT) A Phase 3 Placebo-controlled Study of Milvexian after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack (recruiting)

Medarbejdere

Læger

• Forsknings- og uddannelsesansvarlig overlæge, klinisk lektor, ph.d., Boris Modrau
• Afdelingslæge, ph.d., Krystian Figlewski
• Overlæge Søren Bruno Elmgren
• Afdelingslæge Jakob Schaefer
• Afdelingslæge, Mirko Porobic
• Afdelingslæge Victoria Hansen
• Afdelingslæge Anna Maria Strømmen 

Forskningssygeplejersker

• Nina Hjort Jensen, forskningssygeplejerske, cand.scient.san.publ
• Maiken Falkesgaard Hansen, forskningssygeplejerske 

Forskningssekretær

• Maria Christiansen, forskningssekretær
  
  

Samarbejdspartnere

• Aalborg Universitet
• Danish Center for Clinical Health Services Research
• Center for Neuroteknologi og Rehabilitering (CNR)
• Dansk Stroke Register (DANStroke)
• Dansk Stroke Center

Udvalgte publikationer

• Remote ischemic conditioning in patients with acute stroke: a multicenter randomised, patient-assessor blinded, sham-controlled study. Blauenfeldt RA, Hjort N, Valentin JB, Homburg A-M, Modrau B, Sandal BF, Gude MF, Hougaard KD, Damgaard D, Poulsen M, Diedrichsen T, Schmitz ML, vWeitzel-Mudersbach P, Christensen AA, Figlewski K, Grove E , Hreiðarsdóttir MK, Lassesen MH, Mikkelsen S, Væggemose U, Juelsgaard P, Kirkegaard H, Rostgaard-Knudsen M, Degn N, Vestergaard S, Damsbo AG, Iversen AB, Mortensen JK, Petersson J, Christensen T, Behrndtz AB, Bøtker HE, Gaist D, Fisher M, Hess DC, Johnsen SP, Simonsen CZ, Andersen G. JAMA. 2023;330(13):1236-1246. doi:10.1001/jama.2023.16893
  
  
• Transport strategy in patients with symptoms of acute large-vessel occlusion stroke TRIAGE-STROKE a randomized trial. Behrndtz A, Blauenfeldt R, Johnsen S, Valentin J, Gude M, Al-Jazi M, von Weitzel-Mudersbach P, Modrau B, Damgaard D, Hougaard K, Hjort N, Diedrichsen T, Poulsen M, Schmitz ML, Fisher M, Andersen G, Simonsen C. Stroke. 2023;54:00–00. DOI: 10.1161/STROKEAHA.123.043875
  
  
• Lasting impairments following transient ischemic attack and minor stroke: a systematic review protocol. Hede Ebbesen B, Modrau B, Kontou E, Finch E, Crowfoot G, Crow J, Heron N, Hodson T, Skrubbeltrang C, Turner G. Frontiers in Neurology 14, 2023. DOI 10.3389/fneur.2023.1177309
  
  
• Quality in stroke care during the early phases of the COVID-19 pandemic: A nationwide study Blauenfeldt RA, Hedegaard JN, Kruuse C, Gaist D, Wienecke T, Modrau B, Damgaard D, Johnsen SP, Andersen G, Simonsen CZ. European Stroke Journal. 2022. doi.org/10.1177/23969873221139695
  
  
• COVID-19 did not result in increased hospitalization for stroke and transient ischemic attack. A nationwide study. Simonsen CZ, Blauenfeldt RA, Hedegaard JN, Kruuse C, Gaist D, Wienecke T, Modrau B, Johnsen SP, Andersen G. Eur J Neurol. 2022; 00:1–6. doi:10.1111/ene.15350
  
  
• Left Atrial Appendage Occlusion versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation: Rationale and Design of the Multicenter Randomized Occlusion-AF Trial. Korsholm K, Damgaard D, Valentin JB, Packer EJS, Odenstedt J, Sinisalo J, Putaala J, Næss H, Al-Jazi MA, Karsson J-K, Pontoppidan J, Modrau B, Hjort J, Matzen KL, Johnsen SP, Nielsen-Kudsk JE. American Heart Journal 2022; 243: 28-38
  
  
• Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial. Sharma M, Smith EE, Pearce LA, Shoamanesh A, Perera KS, Coutts SB, Damgaard D, Ameriso SF, Rha JH, Modrau B, Yoon BW, Romano M, Messé SR, Barlinn J, Lambeck J, Saad F, Berkowitz SD, Mundl H, Connolly SJ, Hart RG; NAVIGATE ESUS MIND MRI Substudy Investigators. Stroke. Stroke 2022; 53(1): 45-52
  
  
• Perfusion changes in the infarct core and penumbra in patients with acute ischemic stroke treated with theophylline as an add-on to thrombolytic therapy: A randomized clinical trial subgroup analysis. Modrau B, Winder A, Hjort N, Johansen MN, Andersen G, MD, Fiehler J, Vorum H, Forkert ND. Clinical Neuroradiology 2021. https://doi.org/10.1007/s00062-021-01029-x
  
  
• Machine learning-based prediction of brain tissue infarction in patients with acute ischemic stroke treated with theophylline as an add-on to thrombolytic therapy: A randomized clinical trial subgroup analysis. Modrau B, Winder A, Hjort N, Johansen MN, Andersen G, Fiehler J, Vorum H, Forkert ND. 2021 Frontiers in Neurology; 12, 8 s., 613029
  
  
• Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. Modrau B, Andersen G, Mikkelsen IK, Nielsen A, Hansen MB, Johansen MB, et al. Stroke. 2020;51(7):1983–90
  
  
• Acute Ischemic Stroke in Late Pregnancy Treated with Intravenous Thrombolysis and Endovascular Therapy. Szuchy Kristiansen, E., Holm Vestergaard, H., Modrau, B., Oppel, L. MCase Reports in Neurology, 2019, s. 41-46
  
  
• MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. Thomalla, Götz; Simonsen, Claus Z; Boutitie, Florent; Andersen, Grethe; Berthezene, Yves; Cheng, Bastian; Cheripelli, Bharath; Cho, Tae-Hee; Fazekas, Franz; Fiehler, Jens; Ford, Ian; Galinovic, Ivana; Gellissen, Susanne; Golsari, Amir; Gregori, Johannes; Günther, Matthias; Guibernau, Jorge; Häusler, Karl Georg; Hennerici, Michael; Kemmling, André; Marstrand, Jacob; Modrau, Boris; Neeb, Lars; Perez de la Ossa, Natalia; Puig, Josep; Ringleb, Peter; Roy, Pascal; Scheel, Enno; Schonewille, Wouter; Serena, Joaquin; Sunaert, Stefan; Villringer, Kersten; Wouters, Anke; Thijs, Vincent; Ebinger, Martin; Endres, Matthias; Fiebach, Jochen B; Lemmens, Robin; Muir, Keith W; Nighoghossian, Norbert; Pedraza, Salvador; Gerloff, Christian; WAKE-UP Investigators. The New England Journal of Medicine, Bind 379, Nr. 7, 16.08.2018, s. 611-622.
  
  
• Neuroregeneration and Vascular Protection by Citalopram in Acute Ischemic Stroke (TALOS): A Randomized controlled Study. Kraglund, Kristian Lundsgaard; Mortensen, Janne Kaergaard; Damsbo, Andreas Gammelgaard; Modrau, Boris; Simonsen, Sofie Amalie; Iversen, Helle Klingenberg; Madsen, Morten; Grove, Erik Lerkevang; Johnsen, Søren Paaske; Andersen, Grethe. Stroke, Bind 49, Nr. 11, 11.2018, s. 2568-2576
  
  
• Theophylline as an add-on to thrombolytic therapy in acute ischaemic stroke (TEA-Stroke): A randomized, double-blinded, placebo-controlled, two-centre phase II study.Modrau B, Hjort N, Østergaard L, Mouridsen K, Andersen G, Bach FW. European Stroke Journal 2016; 0(0): 1–7