Healthcare Professionels

To perform prospective observational and randomized studies to improve the knowledge regarding risk and treatment of sequelae to colorectal/anal/bladder/cervical/prostate cancer.

The studies will be performed in close collaboration with the relevant national Danish multidisciplinary cancer group.

• Professor, dr.med. Søren Laurberg, Aarhus University (chairman of the research center)
• Professor, dr.med. Peter Christensen, Aarhus University Hospital (chairman of the surgical clinical center in Aarhus)
• Professor, dr.med. Klaus Krogh, Aarhus University Hospital (chairman of the medical GI center)
• Professor,dr.med. Asbjørn M. Drewes, Aalborg University Hospital (chairman of the medical GI)

Haas, S., Faaborg, P.  Liao, D.,  Laurberg, S., Gregersen, H., Lundby, L., Christensen, P. and Krogh, K. (2018). Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe. Acta Oncologica. 57,(4):465 - 472.

Juul, T., Elfeki, H., Christensen, P., Laurberg S., Emmertsen K.J., Bager, P. (2018). Normative Data for the Low Anterior Resection Syndrome Score (LARS Score). Annals of Surgery

Damsgaard, B., Dalby, H. R., Krogh, K., Jørgensen, S. M. D., Arveschough, A. K., Agnholt, J., Dahlerup, J. F. and Jørgensen, S. P.(2018). Long-term effect of medical treatment of diarrhoea in 377 patients with SeHCAT scan diagnosed bile acid malabsorption from 2003 to 2016; a retrospective study . Alimentary Pharmacology & Therapeutics. 47(7):951-957

Haas, S., Faaborg, P., Gram, M., Lundby, L., Brock, C., Drewes, A. M., Laurberg, S., Krogh, K. and Christensen, P.(2018). Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer. Radiotherapy and Oncology, 128:369–374.

 Jørgensen, J.B.,  Bondeven, P., Iversen L.H., Laurberg S. og Pedersen,  B.G. (2018). Pelvic insufficiency fractures frequently occur following preoperative chemo-radiotherapy for rectal cancer – a nationwide MRI study. Colorectal Dis. 20 (10):873-880

Yde, J., Larsen, H. M., Laurberg, S., Krogh, K. and Møller, H. B.(2018). Chronic diarrhoea following surgery for colon cancer—frequency, causes and treatment options. Int. J. Colorectal Dis. 33 (6):683–694

Thyø, A., Emmertsen, K.J. and Laurberg S.(2018). The Rectal Cancer Female Sexuality Score: Development and Validation of a Scoring System for Female Sexual Function After Rectal Cancer Surgery. Diseases of the Colon & Rectum. 61(6):656–666

Bertelsen, C.A. , Effeki, H., Neuenschwander, A.U., Laurberg S., Kristensen, B., and Emmertsen, K.J.(2018). The risk of long-term bowel dysfunction after resection for sigmoid adenocarcinoma: a cross sectional survey comparing complete mesocolic excision with conventional surgery. Colorectal Dis. 20:256-266

Jakobsen, I.H., Jeppesen, M.M., Simard, S., Thaysen, H.V., Laurberg, S. and Juul, T.(2018). Initial validation of the Danish version of the Fear of Cancer Recurrence Inventory (FCRI) in colorectal cancer patients. J. of Cancer Survivorship. 12(6):723-732

Elfeki H, Thyø A, Nepogodiev D, Pinkney TD, White M, Laurberg S, Christensen P and the Colostomy Impact Study Group.(2018). Patient and healthcare professional perceptions of colostomy-related problems and their impact on quality of life following rectal cancer surgery. BJS Open.2(5):336-344

Mortensen, A.R., Thyø, A., Emmertsen, K.J. and Laurberg. S.(2018). Chronic pain after rectal cancer surgery-development and validation of a scoring system. Colorectal Dis. 21:90-99

Elfeki, H.,  Larsen, H.M., Emmertsen, K.J., Christensen, P., Youssef, M., Khafagy, W.,Omar, W.and Laurberg. S.(2019). Bowel dysfunction after sigmoid resection for cancer and its impact on quality of life. BJS. 106:142-151

Systematic screening for late sequelae after colorectal cancer

We are currently exploring the feasibility of a new approach to follow up after colorectal cancer (CRC). Via online surveys we aim at identifying all patients requiring treatment of late sequelae after CRC.

Surgically treated CRC patients receive a link to an online survey 3, 12, 24, and 36 months after surgery. Patients who have had a temporary diverting stoma also receive the survey 3 months after the stoma reversal. The survey can be completed on a computer, mobile phone, or tablet. Patients who are not online receive a paper version of the questionnaire.

The survey consists of validated questionnaires and a number of ad hoc items covering all known, and potentially treatable, late sequelae after CRC. Both colon- and rectal cancer patients answer questions about bowel function, diet and quality of life, while the survey for rectal cancer patients in addition includes questions regarding urinary- and sexual function and chronic pain.

Patients who indicate late sequelae and an interest in being contacted, receive a call from the project nurse, who presents treatment options and refers to specialists, if relevant.

Measuring the effect of treatment of late sequelae

All patients who receive treatment for late sequelae such as bowel-, urinary-, or sexual dysfunction, or chronic pain will be treated according to pre-defined treatment algorithms. Each patient will complete a detailed online survey at baseline, and again 3 and 12 months after the last visit. The survey is aiming at the specific problem the patient is being treated for, and the purpose is to measure the effect of all treatments for late sequelae offered in the Late sequelae clinic.