Stroke

Interesseområder

Vores patientnære, primært kliniske forskning dækker aktuelt en bred vifte af forskningsprojekter. Vi deltager i nationale og internationale multicenterstudier, som optimerer det præhospitale forløb (visitation og behandling), den akutte behandling (cerebral iskæmi og hæmorrhagi) og sekundærprofylaksen. Vores planlagte og igangværende lokale projekter fokuser på optimering af paraklinisk diagnostik (trombofili og cerebral makroangiopati) og rehabilitation (brain computer interface).

Igangværende projekter

• TRIAGE-Stroke (RCT)
  TReatment strategy In Acute ischemic larGE vessel STROKE: Prioritize thrombolysis or endovascular treatment.
  
  
• RESIST (RCT)
  Remote ischemic conditioning in patients with acute stroke: a multicenter randomized, patient-assessor blinded, sham-controlled study.
  
  
• TENSION (RCT)
  Efficacy and safety of thrombectomy in stroke with extended lesion and extended time window: a randomized, controlled trial.
  
  
• StrokeClose (RCT)
  Prevention of Stroke by Left Artrial Appendage Closure in atrial fibrillation patients after intracerebral hemorrhage: A multicenter Randomized Clinical Trial.
  
  
• Development and preliminary testing of a patient-centered and evidence-based intervention for patients with Transient Ischemic Attack by exploring prognosis, impact on everyday life and return to work
  
  
• STATICH (RCT)
  Study of Antithrombotic Treatment after Intracerebral Haemorrhage.
  
  
• PACIFIC-Stroke (RCT)
  Multicenter, randomized, placebo-controlled, double-blind, parallel group, dose-finding Phase 2 study to evaluate efficacy and safety of BAY 2433334 in patients following an acute non cardioembolic ischemic stroke.
  
  
• AXIOMATIC-SSP (RCT)
  A Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA).
  
  
• ANNEXa-I (RCT)
  A randomized clinical trial of Andexanet Afla in acute intracranial hemorrhage in patients receiving an oral factor Xa Inhibitor.
  
  
• OCCLUSION-AF (RCT)
  The OCCLUSION-AF Trial: Left Atrial Appendage Occlusion versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation. A Multicenter Randomized Clinical Trial.
  
  
• BCI-STAR (RCT)
  A protocol of timed BCI-assisted physiotherapy (BCI training) can significantly improve rehabilitation in upper limb function in post-stroke patients.

• LATIA (cohorte and feasibility RCT)
  Life After Transient Ischemic Attack: To investigate prognosis and impact of Transient Ischemic Attack (TIA). Based on this, design and test an intervention to improve return to everyday life.

Medarbejdere

Læger

• Boris Modrau, Ph.D, specialeansvarlig overlæge, forsknings- og uddannelsesansvarlig, klinisk lektor
• Krystian Figlewski, afdelingslæge, Ph.D.
• Mirko Porobic, afdelingslæge

Forskningssygeplejersker

• Nina Hjort Jensen, forskningssygeplejerske, cand.scient.san.publ
• Maiken Falkesgaard Hansen, forskningssygeplejerske 

Forskningssekretær

• Maria Christiansen, forskningssekretær
  
  

Samarbejdspartnere

• Aalborg Universitet
• Center for Neuroteknologi og Rehabilitering
• Dansk Apopleksi Register
• Dansk Stroke Center
  
  

Udvalgte publikationer

• Modrau B, Andersen G, Mikkelsen IK, Nielsen A, Hansen MB, Johansen MB, et al. Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. Stroke. 2020;51(7):1983–90
  
  
• Szuchy Kristiansen, E., Holm Vestergaard, H., Modrau, B., Oppel, L. M. Acute Ischemic Stroke in Late Pregnancy Treated with Intravenous Thrombolysis and Endovascular Therapy. Case Reports in Neurology, 2019, s. 41-46
  
  
• Thomalla, Götz; Simonsen, Claus Z; Boutitie, Florent; Andersen, Grethe; Berthezene, Yves; Cheng, Bastian; Cheripelli, Bharath; Cho, Tae-Hee; Fazekas, Franz; Fiehler, Jens; Ford, Ian; Galinovic, Ivana; Gellissen, Susanne; Golsari, Amir; Gregori, Johannes; Günther, Matthias; Guibernau, Jorge; Häusler, Karl Georg; Hennerici, Michael; Kemmling, André; Marstrand, Jacob; Modrau, Boris; Neeb, Lars; Perez de la Ossa, Natalia; Puig, Josep; Ringleb, Peter; Roy, Pascal; Scheel, Enno; Schonewille, Wouter; Serena, Joaquin; Sunaert, Stefan; Villringer, Kersten; Wouters, Anke; Thijs, Vincent; Ebinger, Martin; Endres, Matthias; Fiebach, Jochen B; Lemmens, Robin; Muir, Keith W; Nighoghossian, Norbert; Pedraza, Salvador; Gerloff, Christian; WAKE-UP Investigators. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. The New England Journal of Medicine, Bind 379, Nr. 7, 16.08.2018, s. 611-622.
  
  
• Kraglund, Kristian Lundsgaard; Mortensen, Janne Kaergaard; Damsbo, Andreas Gammelgaard; Modrau, Boris; Simonsen, Sofie Amalie; Iversen, Helle Klingenberg; Madsen, Morten; Grove, Erik Lerkevang; Johnsen, Søren Paaske; Andersen, Grethe. Neuroregeneration and Vascular Protection by Citalopram in Acute Ischemic Stroke (TALOS): A Randomized controlled Study.  Stroke, Bind 49, Nr. 11, 11.2018, s. 2568-2576
  
  
• Modrau B, Hjort N, Østergaard L, Mouridsen K, Andersen G, Bach FW. Theophylline as an add-on to thrombolytic therapy in acute ischaemic stroke (TEA-Stroke): A randomized, double-blinded, placebo-controlled, two-centre phase II study. European Stroke Journal 2016; 0(0): 1–7